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Thiazole tautomerase

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Thiazole tautomerase
Identifiers
EC no.5.3.99.10
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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Thiazole tautomerase (EC 5.3.99.10, tenI (gene)) is an enzyme with systematic name 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase.[1] This enzyme catalyses the following chemical reaction

2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate

The enzyme catalyses the irreversible aromatization of the thiazole moiety of 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate.

References

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  1. ^ Hazra AB, Han Y, Chatterjee A, Zhang Y, Lai RY, Ealick SE, Begley TP (June 2011). "A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase". Journal of the American Chemical Society. 133 (24): 9311–9. doi:10.1021/ja1110514. PMC 3116082. PMID 21534620.
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